POFUT1 POINT-MUTATIONS THAT DISRUPT O-FUCOSYLTRANSFERASE ACTIVITY DESTABILIZE THE PROTEIN AND ABOLISH NOTCH1 SIGNALING DURING MOUSE SOMITOGENESIS.

Pofut1 point-mutations that disrupt O-fucosyltransferase activity destabilize the protein and abolish Notch1 signaling during mouse somitogenesis.

The segmental pattern of the vertebrate body is established via the periodic formation of somites from the presomitic mesoderm (PSM).This periodical process is controlled by the cyclic and synchronized activation of Notch signaling in the PSM.Protein O-fucosyltransferase1 (Pofut1), which transfers O-fucose to the bl2420pt EGF domains of the Notch1

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Optimal Allocation of Multi-Type Vaccines in a Two-Dose Vaccination Campaign for Epidemic Control: A Case Study of COVID-19

As a typical case of the optimal planning for the provision of restricted medical resources, widespread vaccination is considered an effective and sustainable way to prevent and control large-scale novel coronavirus disease 2019 (COVID-19) outbreaks.However, an initial supply shortage of vaccines is inevitable because of the narrow production and l

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Use of a language intervention to reduce vaccine hesitancy

Abstract Vaccine hesitancy is a major global challenge facing COVID-19 immunization apple mtxn2ll/a programs.Its main source is low public trust in the safety and effectiveness of the vaccine.In a preregistered experimental study, we investigated how using a foreign language when communicating COVID-19 vaccine information influences vaccine accepta

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